Aged garlic extract inhibits CD36 expression in human macrophages via modulation of the PPARgamma pathway.
Morihara N, Ide N, Weiss N.
Center for Vascular Medicine, Section Angiology, Medical Policlinic, University of Munich Medical Center, Pettenkoferstrasse 8A, D-80336 Munich, Germany.
Abstract
Expression of CD36 scavenger receptors on macrophages is involved in oxidized low-density lipoprotein uptake and foam cell formation during atherosclerotic lesion development. We examined the effects of aged garlic extract (AGE), a garlic preparation enriched in water-soluble cysteinyl moieties that increases cellular total thiols and glutathione concentrations, on CD36 expression in human monocytes/macrophages (THP-1 cells and primary human monocytes). Compared to control, AGE (1-5 mg/mL) dose-dependently and significantly suppressed CD36 expression up to by 61.8 +/- 7.4% in THP-1-derived macrophages and up to 50.5 +/- 7.1% in primary human macrophages, respectively. Furthermore, AGE prevented induction of CD36 expression by the peroxisome proliferator activator receptor (PPAR) gamma agonist troglitazone, and decreased binding of nuclear proteins to a PPARgamma response element. AGE showed a stronger inhibitory effect on CD36 expression in THP-1 cells during simultaneous incubation with phorbol 12-myristate 13-acetate (PMA) compared to cells that had been pre-incubated with PMA. Furthermore, AGE decreased CD11b expression in a dose-dependent manner. These data indicate that AGE inhibits CD36 expression by modulating the PPARgamma pathway in human macrophages and monocytes differentiation into macrophages, and suggests that the extract could be useful for the prevention of atherosclerotic lesions.
Copyright (c) 2010 John Wiley & Sons, Ltd.
PMID: 20091745 [PubMed - in process]
August 30, 2010
Testimoni Hj Ahmad Laili, Klang
Testimoni Tuan Haji Ahmad Laili, 62 tahun @ agen Batu 4, Jalan Kapar, Klang
Tn Hj ni menghidap diabetic yg tinggi..di sini beliau berkongsi tentang bisul di kaki yang dah lama tak baik2 sampai tahap dah berlubang, tentang penyakit diabetes nya yg dah tak payah lagi inject insulin, tentang pengalaman makcik nya yang menghidap penyakit gout smpai tahap bila nak solat kena duduk dan sekarang ni dah boleh solat macam biasa takyah duduk lagi, makcik nya sorang lagi pun diabetes nya dah turun...
So jangan tunggu lagi, dah ramai yg mendapat kebaikan dari Black Garlic ni...
Tn Hj ni menghidap diabetic yg tinggi..di sini beliau berkongsi tentang bisul di kaki yang dah lama tak baik2 sampai tahap dah berlubang, tentang penyakit diabetes nya yg dah tak payah lagi inject insulin, tentang pengalaman makcik nya yang menghidap penyakit gout smpai tahap bila nak solat kena duduk dan sekarang ni dah boleh solat macam biasa takyah duduk lagi, makcik nya sorang lagi pun diabetes nya dah turun...
So jangan tunggu lagi, dah ramai yg mendapat kebaikan dari Black Garlic ni...
August 29, 2010
Testimoni Pn Kam
Testimoni dari Pn Kam, yang telah menghidap Migraine (Major). Sekarang tiada lagi Migarine attack seperti yang selalu.
Selain itu, Pn Kam juga telah mengesyorkan Black Garlic kepada bapa mertua nya mempunyai masalah perut (purging) yang agak serius. Kini setelah makan Black Garlic, penyakit nya telah sembuh, tiada lagi purging.
August 28, 2010
Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus.
Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus.
Lee YM, Gweon OC, Seo YJ, Im J, Kang MJ, Kim MJ, Kim JI.
School of Food and Life Science, Biohealth Product Research Center, Institute for Food Sciences, Inje University, 607 Obang-dong, Gimhae, Gyeongnam 621-749, Korea.
Abstract
Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes. The antioxidant activity of garlic and aged black garlic was measured as the activity in scavenging free radicals by the trolox equivalent antioxidant capacity (TEAC) assay. Three week-old db/db mice were fed AIN-93G diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Hepatic levels of lipid peroxides and activities of antioxidant enzymes were measured. TEAC values of garlic and aged black garlic were 13.3 +/- 0.5 and 59.2 +/- 0.8 micromol/g wet weight, respectively. Consumption of aged black garlic significantly decreased hepatic thiobarbituric acid reactive substances (TBARS) level compared with the garlic group which showed lower TBARS level than control group (p<0.05). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of garlic and aged black garlic group were significantly elevated compared to the control group. Catalase (CAT) activity of aged black garlic group was increased compared with the control group. These results show that aged black garlic exerts stronger antioxidant activity than garlic in vitro and in vivo, suggesting garlic and aged black garlic, to a greater extent, could be useful in preventing diabetic complications. PMID: 20016716 [PubMed - in process]PMCID: PMC2788179
Lee YM, Gweon OC, Seo YJ, Im J, Kang MJ, Kim MJ, Kim JI.
School of Food and Life Science, Biohealth Product Research Center, Institute for Food Sciences, Inje University, 607 Obang-dong, Gimhae, Gyeongnam 621-749, Korea.
Abstract
Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes. The antioxidant activity of garlic and aged black garlic was measured as the activity in scavenging free radicals by the trolox equivalent antioxidant capacity (TEAC) assay. Three week-old db/db mice were fed AIN-93G diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Hepatic levels of lipid peroxides and activities of antioxidant enzymes were measured. TEAC values of garlic and aged black garlic were 13.3 +/- 0.5 and 59.2 +/- 0.8 micromol/g wet weight, respectively. Consumption of aged black garlic significantly decreased hepatic thiobarbituric acid reactive substances (TBARS) level compared with the garlic group which showed lower TBARS level than control group (p<0.05). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of garlic and aged black garlic group were significantly elevated compared to the control group. Catalase (CAT) activity of aged black garlic group was increased compared with the control group. These results show that aged black garlic exerts stronger antioxidant activity than garlic in vitro and in vivo, suggesting garlic and aged black garlic, to a greater extent, could be useful in preventing diabetic complications. PMID: 20016716 [PubMed - in process]PMCID: PMC2788179
August 26, 2010
Aged garlic extract retards progression of coronary artery calcification
Aged garlic extract retards progression of coronary artery calcification.
Budoff M.
Division of Cardiology, Harbor-UCLA Medical Center, Torrance, CA, USA.
Abstract
Prospective epidemiologic studies have identified several risk factors for heart disease, and most can be the target of risk reduction interventions. The most widely recognized risk factors for atherosclerotic cardiovascular disease (ASCVD) include age, gender, cigarette smoking, sedentary lifestyle, elevated LDL, reduced HDL, hypertension, and diabetes. The consistency of associations between these factors and ASCVD risk across populations is substantial. Our understanding of the pathogenesis and etiology of coronary ASCVD, as well as its clinical implications, has grown tremendously over the past 20 y. The role garlic might play in treating ASCVD has been postulated for many years, but until recently no studies on garlic's ability to inhibit the atherosclerotic process have been reported. A pilot study evaluating coronary artery calcification and the effect of garlic therapy in a group of patients who were also on statin therapy suggested incremental benefits. The implications of this study must be put in context of the potential importance of early atherosclerosis detection and prevention.
PMID: 16484554 [PubMed - indexed for MEDLINE]
Budoff M.
Division of Cardiology, Harbor-UCLA Medical Center, Torrance, CA, USA.
Abstract
Prospective epidemiologic studies have identified several risk factors for heart disease, and most can be the target of risk reduction interventions. The most widely recognized risk factors for atherosclerotic cardiovascular disease (ASCVD) include age, gender, cigarette smoking, sedentary lifestyle, elevated LDL, reduced HDL, hypertension, and diabetes. The consistency of associations between these factors and ASCVD risk across populations is substantial. Our understanding of the pathogenesis and etiology of coronary ASCVD, as well as its clinical implications, has grown tremendously over the past 20 y. The role garlic might play in treating ASCVD has been postulated for many years, but until recently no studies on garlic's ability to inhibit the atherosclerotic process have been reported. A pilot study evaluating coronary artery calcification and the effect of garlic therapy in a group of patients who were also on statin therapy suggested incremental benefits. The implications of this study must be put in context of the potential importance of early atherosclerosis detection and prevention.
PMID: 16484554 [PubMed - indexed for MEDLINE]
August 21, 2010
Antioxidant health effects of aged garlic extract
Antioxidant health effects of aged garlic extract.
Borek C.
Department of Community Health and Family Medicine, Nutrition and Infectious Diseases Unit, Tufts University School of Medicine, Boston, MA 02111, USA.
Abstract
Oxidative modification of DNA, proteins and lipids by reactive oxygen species (ROS) plays a role in aging and disease, including cardiovascular, neurodegenerative and inflammatory diseases and cancer. Extracts of fresh garlic that are aged over a prolonged period to produce aged garlic extract (AGE) contain antioxidant phytochemicals that prevent oxidant damage. These include unique water-soluble organosulfur compounds, lipid-soluble organosulfur components and flavonoids, notably allixin and selenium. Long-term extraction of garlic (up to 20 mo) ages the extract, creating antioxidant properties by modifying unstable molecules with antioxidant activity, such as allicin, and increasing stable and highly bioavailable water-soluble organosulfur compounds, such as S-allylcysteine and S-allylmercaptocysteine. AGE exerts antioxidant action by scavenging ROS, enhancing the cellular antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, and increasing glutathione in the cells. AGE inhibits lipid peroxidation, reducing ischemic/reperfusion damage and inhibiting oxidative modification of LDL, thus protecting endothelial cells from the injury by the oxidized molecules, which contributes to atherosclerosis. AGE inhibits the activation of the oxidant-induced transcription factor, nuclear factor (NF)-kappa B, which has clinical significance in human immunodeficiency virus gene expression and atherogenesis. AGE protects DNA against free radical--mediated damage and mutations, inhibits multistep carcinogenesis and defends against ionizing radiation and UV-induced damage, including protection against some forms of UV-induced immunosuppression. AGE may have a role in protecting against loss of brain function in aging and possess other antiaging effects, as suggested by its ability to increase cognitive functions, memory and longevity in a senescence-accelerated mouse model. AGE has been shown to protect against the cardiotoxic effects of doxorubicin, an antineoplastic agent used in cancer therapy and against liver toxicity caused by carbon tetrachloride (an industrial chemical) and acetaminophen, an analgesic. Substantial experimental evidence shows the ability of AGE to protect against oxidant-induced disease, acute damage from aging, radiation and chemical exposure, and long-term toxic damage. Although additional observations are warranted in humans, compelling evidence supports the beneficial health effects attributed to AGE, i.e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease.
PMID: 11238807 [PubMed - indexed for MEDLINE]
Borek C.
Department of Community Health and Family Medicine, Nutrition and Infectious Diseases Unit, Tufts University School of Medicine, Boston, MA 02111, USA.
Abstract
Oxidative modification of DNA, proteins and lipids by reactive oxygen species (ROS) plays a role in aging and disease, including cardiovascular, neurodegenerative and inflammatory diseases and cancer. Extracts of fresh garlic that are aged over a prolonged period to produce aged garlic extract (AGE) contain antioxidant phytochemicals that prevent oxidant damage. These include unique water-soluble organosulfur compounds, lipid-soluble organosulfur components and flavonoids, notably allixin and selenium. Long-term extraction of garlic (up to 20 mo) ages the extract, creating antioxidant properties by modifying unstable molecules with antioxidant activity, such as allicin, and increasing stable and highly bioavailable water-soluble organosulfur compounds, such as S-allylcysteine and S-allylmercaptocysteine. AGE exerts antioxidant action by scavenging ROS, enhancing the cellular antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, and increasing glutathione in the cells. AGE inhibits lipid peroxidation, reducing ischemic/reperfusion damage and inhibiting oxidative modification of LDL, thus protecting endothelial cells from the injury by the oxidized molecules, which contributes to atherosclerosis. AGE inhibits the activation of the oxidant-induced transcription factor, nuclear factor (NF)-kappa B, which has clinical significance in human immunodeficiency virus gene expression and atherogenesis. AGE protects DNA against free radical--mediated damage and mutations, inhibits multistep carcinogenesis and defends against ionizing radiation and UV-induced damage, including protection against some forms of UV-induced immunosuppression. AGE may have a role in protecting against loss of brain function in aging and possess other antiaging effects, as suggested by its ability to increase cognitive functions, memory and longevity in a senescence-accelerated mouse model. AGE has been shown to protect against the cardiotoxic effects of doxorubicin, an antineoplastic agent used in cancer therapy and against liver toxicity caused by carbon tetrachloride (an industrial chemical) and acetaminophen, an analgesic. Substantial experimental evidence shows the ability of AGE to protect against oxidant-induced disease, acute damage from aging, radiation and chemical exposure, and long-term toxic damage. Although additional observations are warranted in humans, compelling evidence supports the beneficial health effects attributed to AGE, i.e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease.
PMID: 11238807 [PubMed - indexed for MEDLINE]
Antioxidant health effects of aged garlic extract
Antioxidant health effects of aged garlic extract.
Borek C.
Department of Community Health and Family Medicine, Nutrition and Infectious Diseases Unit, Tufts University School of Medicine, Boston, MA 02111, USA.
Abstract
Oxidative modification of DNA, proteins and lipids by reactive oxygen species (ROS) plays a role in aging and disease, including cardiovascular, neurodegenerative and inflammatory diseases and cancer. Extracts of fresh garlic that are aged over a prolonged period to produce aged garlic extract (AGE) contain antioxidant phytochemicals that prevent oxidant damage. These include unique water-soluble organosulfur compounds, lipid-soluble organosulfur components and flavonoids, notably allixin and selenium. Long-term extraction of garlic (up to 20 mo) ages the extract, creating antioxidant properties by modifying unstable molecules with antioxidant activity, such as allicin, and increasing stable and highly bioavailable water-soluble organosulfur compounds, such as S-allylcysteine and S-allylmercaptocysteine. AGE exerts antioxidant action by scavenging ROS, enhancing the cellular antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, and increasing glutathione in the cells. AGE inhibits lipid peroxidation, reducing ischemic/reperfusion damage and inhibiting oxidative modification of LDL, thus protecting endothelial cells from the injury by the oxidized molecules, which contributes to atherosclerosis. AGE inhibits the activation of the oxidant-induced transcription factor, nuclear factor (NF)-kappa B, which has clinical significance in human immunodeficiency virus gene expression and atherogenesis. AGE protects DNA against free radical--mediated damage and mutations, inhibits multistep carcinogenesis and defends against ionizing radiation and UV-induced damage, including protection against some forms of UV-induced immunosuppression. AGE may have a role in protecting against loss of brain function in aging and possess other antiaging effects, as suggested by its ability to increase cognitive functions, memory and longevity in a senescence-accelerated mouse model. AGE has been shown to protect against the cardiotoxic effects of doxorubicin, an antineoplastic agent used in cancer therapy and against liver toxicity caused by carbon tetrachloride (an industrial chemical) and acetaminophen, an analgesic. Substantial experimental evidence shows the ability of AGE to protect against oxidant-induced disease, acute damage from aging, radiation and chemical exposure, and long-term toxic damage. Although additional observations are warranted in humans, compelling evidence supports the beneficial health effects attributed to AGE, i.e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease.
PMID: 11238807 [PubMed - indexed for MEDLINE]
Borek C.
Department of Community Health and Family Medicine, Nutrition and Infectious Diseases Unit, Tufts University School of Medicine, Boston, MA 02111, USA.
Abstract
Oxidative modification of DNA, proteins and lipids by reactive oxygen species (ROS) plays a role in aging and disease, including cardiovascular, neurodegenerative and inflammatory diseases and cancer. Extracts of fresh garlic that are aged over a prolonged period to produce aged garlic extract (AGE) contain antioxidant phytochemicals that prevent oxidant damage. These include unique water-soluble organosulfur compounds, lipid-soluble organosulfur components and flavonoids, notably allixin and selenium. Long-term extraction of garlic (up to 20 mo) ages the extract, creating antioxidant properties by modifying unstable molecules with antioxidant activity, such as allicin, and increasing stable and highly bioavailable water-soluble organosulfur compounds, such as S-allylcysteine and S-allylmercaptocysteine. AGE exerts antioxidant action by scavenging ROS, enhancing the cellular antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase, and increasing glutathione in the cells. AGE inhibits lipid peroxidation, reducing ischemic/reperfusion damage and inhibiting oxidative modification of LDL, thus protecting endothelial cells from the injury by the oxidized molecules, which contributes to atherosclerosis. AGE inhibits the activation of the oxidant-induced transcription factor, nuclear factor (NF)-kappa B, which has clinical significance in human immunodeficiency virus gene expression and atherogenesis. AGE protects DNA against free radical--mediated damage and mutations, inhibits multistep carcinogenesis and defends against ionizing radiation and UV-induced damage, including protection against some forms of UV-induced immunosuppression. AGE may have a role in protecting against loss of brain function in aging and possess other antiaging effects, as suggested by its ability to increase cognitive functions, memory and longevity in a senescence-accelerated mouse model. AGE has been shown to protect against the cardiotoxic effects of doxorubicin, an antineoplastic agent used in cancer therapy and against liver toxicity caused by carbon tetrachloride (an industrial chemical) and acetaminophen, an analgesic. Substantial experimental evidence shows the ability of AGE to protect against oxidant-induced disease, acute damage from aging, radiation and chemical exposure, and long-term toxic damage. Although additional observations are warranted in humans, compelling evidence supports the beneficial health effects attributed to AGE, i.e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease.
PMID: 11238807 [PubMed - indexed for MEDLINE]
Agen di Batu Pahat Johor
Agen di Batu Pahat, Johor
En Syed Husin, hubungi 0197786773
En Husin adalah agen yang paling TOP sekarang, dengan pengambilan STOCK yang begitu tinggi sekali..
Sesiapa berada di area Batu Pahat Johor, boleh hubungi En Husin untuk jumpa...dah banyak positif feedback yang saya terima dari En Husin
En Syed Husin, hubungi 0197786773
En Husin adalah agen yang paling TOP sekarang, dengan pengambilan STOCK yang begitu tinggi sekali..
Sesiapa berada di area Batu Pahat Johor, boleh hubungi En Husin untuk jumpa...dah banyak positif feedback yang saya terima dari En Husin
August 18, 2010
Agen di Ampang
Agen di Ampang
Orang area Ampang, bleh contact
En Lokman di talian 0193553020 untuk dapatkan Black Garlic anda...
Orang area Ampang, bleh contact
En Lokman di talian 0193553020 untuk dapatkan Black Garlic anda...
PROMOSI AGENT
Berminat untuk menjadi agent Black Garlic?
Kini terdapat promosi untuk mereka yang berminat menjadi agent Black Garlic.
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Mari membantu mereka yang mempunyai masalah kesihatan...
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Facebook Garlichitam Msia
Immunomodulatory effects of aged garlic extract.
Immunomodulatory effects of aged garlic extract.
Kyo E, Uda N, Kasuga S, Itakura Y.
Healthcare Research Institute, Wakunaga Pharmaceutical Company, Ltd., Koda-cho, Takata-gun, Hiroshima 739-1195, Japan. kyo_e@wakunaga@co.jp
Abstract
Using various kinds of models, we examined the effects of aged garlic extract (AGE) on immune functions. In the immunoglobulin (Ig)E-mediated allergic mouse model, AGE significantly decreased the antigen-specific ear swelling induced by picryl chloride ointment to the ear and intravenous administration of antitrinitrophenyl antibody. In the transplanted carcinoma cell model, AGE significantly inhibited the growth of Sarcoma-180 (allogenic) and LL/2 lung carcinoma (syngenic) cells transplanted into mice. Concomitantly, increases in natural killer (NK) and killer activities of spleen cells were observed in Sarcoma-180--bearing mice administered AGE. In the psychological stress model, AGE significantly prevented the decrease in spleen weight and restored the reduction of anti-SRBC hemolytic plaque-forming cells caused by the electrical stress. These studies strongly suggest that AGE could be a promising candidate as an immune modifier, which maintains the homeostasis of immune functions; further studies are warranted to determine when it is most beneficial.
PMID: 11238820 [PubMed - indexed for MEDLINE]
Kyo E, Uda N, Kasuga S, Itakura Y.
Healthcare Research Institute, Wakunaga Pharmaceutical Company, Ltd., Koda-cho, Takata-gun, Hiroshima 739-1195, Japan. kyo_e@wakunaga@co.jp
Abstract
Using various kinds of models, we examined the effects of aged garlic extract (AGE) on immune functions. In the immunoglobulin (Ig)E-mediated allergic mouse model, AGE significantly decreased the antigen-specific ear swelling induced by picryl chloride ointment to the ear and intravenous administration of antitrinitrophenyl antibody. In the transplanted carcinoma cell model, AGE significantly inhibited the growth of Sarcoma-180 (allogenic) and LL/2 lung carcinoma (syngenic) cells transplanted into mice. Concomitantly, increases in natural killer (NK) and killer activities of spleen cells were observed in Sarcoma-180--bearing mice administered AGE. In the psychological stress model, AGE significantly prevented the decrease in spleen weight and restored the reduction of anti-SRBC hemolytic plaque-forming cells caused by the electrical stress. These studies strongly suggest that AGE could be a promising candidate as an immune modifier, which maintains the homeostasis of immune functions; further studies are warranted to determine when it is most beneficial.
PMID: 11238820 [PubMed - indexed for MEDLINE]
Agen di Batu 3, Shah Alam
Agen kasawan Batu 3, Shah Alam
Mereka yang berada di batu 3, lebih tepat lagi kawasan perindustrian batu 3, kalau nak beli Black Garlic, bleh hubungi:-
Puan Rekamsinah @ Kam di 0126479116
Mereka yang berada di batu 3, lebih tepat lagi kawasan perindustrian batu 3, kalau nak beli Black Garlic, bleh hubungi:-
Puan Rekamsinah @ Kam di 0126479116
Pengalaman Puan Kam dengan Black Garlic
Kepada penghidap MIGRAINE, Black Garlic memang berkesan untuk anda!!!
Makcik saya Pn Rekamsinah adalah penghidap MIGRAINE yang kronik..Selepas mengambil Black Garlic selama 2 minggu, dengan mengikut sukatan yang dicadangkan, ALHAMDULILLAH...TIADA LANGSUNG SEBARANG TANDA2 SEPERTI NAK KENA MIGRAINE SEPERTI SELALU SEBELUM INI. Menurut makcik saya, kebiasaannya, dahulu, setiap minggu ada sahaja tanda2 macam nak kena Mgraine attack so dia kena la standby kan ubat Migraine all the time..Sekarang selepas 2 minggu, Alhamdullah...tiada langsung tanda2 seperti dulu..
Makcik saya Pn Rekamsinah adalah penghidap MIGRAINE yang kronik..Selepas mengambil Black Garlic selama 2 minggu, dengan mengikut sukatan yang dicadangkan, ALHAMDULILLAH...TIADA LANGSUNG SEBARANG TANDA2 SEPERTI NAK KENA MIGRAINE SEPERTI SELALU SEBELUM INI. Menurut makcik saya, kebiasaannya, dahulu, setiap minggu ada sahaja tanda2 macam nak kena Mgraine attack so dia kena la standby kan ubat Migraine all the time..Sekarang selepas 2 minggu, Alhamdullah...tiada langsung tanda2 seperti dulu..
August 16, 2010
Aged Garlic extract attenuates intracellular oxidative stress
Aged garlic extract attenuates intracellular oxidative stress.
Ide N, Lau BH.
Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, CA, USA.
Abstract
Oxidation of low density lipoprotein (LDL) has been recognized as playing an important role in the initiation and progression of atherosclerosis. We recently reported that aged garlic extract (AGE) inhibited LDL oxidation and minimized oxidized LDL-induced cell injury. In this study, the antioxidant effects of AGE were further examined using bovine pulmonary artery endothelial cells (PAEC) and murine macrophages. Lactate dehydrogenase (LDH) release, as an index of membrane injury, and intracellular glutathione (GSH) levels were determined. Oxidized LDL (Ox-LDL) caused an increase of LDH release and depletion of GSH. Pretreatment with AGE prevented these changes. AGE exhibited an inhibition of Ox-LDL-induced peroxides in PAEC. AGE suppressed peroxides in murine Macrophage (J774 cells) dose-dependently. The J774 cells were also incubated with AGE, interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) and nitric oxide (NO) production was measured. AGE inhibited NO production in J774 cells. In a cell free system, AGE was shown to scavenge H2O2 dose-dependently. Our data demonstrate that AGE can protect the endothelial cells from oxidized LDL-induced injury by preventing depletion of intracellular GSH and by removing peroxides. AGE also reduces levels of NO and peroxides in macrophages. These data suggest that AGE is a useful protective agent against cytotoxicity associated with Ox-LDL and NO, and it may thus be useful for the prevention of atherosclerosis and cardiovascular diseases.
PMID: 10374252 [PubMed - indexed for MEDLINE]
Department of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, CA, USA.
Abstract
Oxidation of low density lipoprotein (LDL) has been recognized as playing an important role in the initiation and progression of atherosclerosis. We recently reported that aged garlic extract (AGE) inhibited LDL oxidation and minimized oxidized LDL-induced cell injury. In this study, the antioxidant effects of AGE were further examined using bovine pulmonary artery endothelial cells (PAEC) and murine macrophages. Lactate dehydrogenase (LDH) release, as an index of membrane injury, and intracellular glutathione (GSH) levels were determined. Oxidized LDL (Ox-LDL) caused an increase of LDH release and depletion of GSH. Pretreatment with AGE prevented these changes. AGE exhibited an inhibition of Ox-LDL-induced peroxides in PAEC. AGE suppressed peroxides in murine Macrophage (J774 cells) dose-dependently. The J774 cells were also incubated with AGE, interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS) and nitric oxide (NO) production was measured. AGE inhibited NO production in J774 cells. In a cell free system, AGE was shown to scavenge H2O2 dose-dependently. Our data demonstrate that AGE can protect the endothelial cells from oxidized LDL-induced injury by preventing depletion of intracellular GSH and by removing peroxides. AGE also reduces levels of NO and peroxides in macrophages. These data suggest that AGE is a useful protective agent against cytotoxicity associated with Ox-LDL and NO, and it may thus be useful for the prevention of atherosclerosis and cardiovascular diseases.
PMID: 10374252 [PubMed - indexed for MEDLINE]
__________________
Agen di Bandar Seri Alam, Johor Bahru
Agen di Johor Bahru 
En Noor Azman bin Abdul Wahid
No 5 Jln Tasek 11
Bandar Seri Alam
81750 Johor Bahru
Johor
019-7535972
Jom org JB!!! try Black Garlic dr En Noor Azman..
En Noor Azman bin Abdul Wahid
No 5 Jln Tasek 11
Bandar Seri Alam
81750 Johor Bahru
Johor
019-7535972
Jom org JB!!! try Black Garlic dr En Noor Azman..
August 15, 2010
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Testimoni En Mazlan, Jitra Kedah
from mazlan abd ghafur
to ab.richpowerhouse@gmail.com
date Sun, Aug 15, 2010 at 10:34 AM
Salam Tuan,
Saya telah membuat pembayaran di atas seperti telah dipersetujui.
Pengalaman : Ibu saya mengidap penyakit darah tinggi & kencing manis. Walaupun tidak serius tetapi hari-hari makan ubat hospital. Setelah mencuba BG, penyakitnya telah kembali normal walupun beliau makan ikut sukahati kerana BG tak berapa sedap katanya. Sekarang saya beli untuk diri sendiri atau jika ada rakan yang nak test, saya akan beri untuk rasa.
Sekian, terima kasih.
to ab.richpowerhouse@gmail.com
date Sun, Aug 15, 2010 at 10:34 AM
Salam Tuan,
Saya telah membuat pembayaran di atas seperti telah dipersetujui.
Pengalaman : Ibu saya mengidap penyakit darah tinggi & kencing manis. Walaupun tidak serius tetapi hari-hari makan ubat hospital. Setelah mencuba BG, penyakitnya telah kembali normal walupun beliau makan ikut sukahati kerana BG tak berapa sedap katanya. Sekarang saya beli untuk diri sendiri atau jika ada rakan yang nak test, saya akan beri untuk rasa.
Sekian, terima kasih.
August 14, 2010
Penyakit berkaitan Sistem Penghadaman
KUALA LUMPUR - Masalah penghadaman adalah antara 10 penyakit paling kronik dan penyebab utama kematian di Malaysia, kata Timbalan Menteri Kesihatan Datuk Rosnah Abdul Rashid Shirlin.
Beliau berkata, pada 2006 dan 2007, penyakit berkaitan sistem penghadaman menduduki tangga ketujuh sebagai penyebab utama kematian di hospital kerajaan dan melonjak ke tangga keenam pada tahun 2008.
"Ini tidak memeranjatkan jika dilihat gaya hidup kebanyakan rakyat Malaysia," katanya ketika melancarkan sambutan Hari Penghadaman Sedunia di Ikano Power Centre di sini semalam.
Rosnah berkata, penyakit berkaitan sistem penghadaman yang paling banyak dihidapi rakyat Malaysia ialah refluks gastroesophageal (GERD), ulser peptik, sindrom kerengsaan usus (IBS) dan kanser usus.
"Penyakit kanser gastrointestinal khususnya, meningkat secara mendadak di Malaysia berdasarkan hakikat bahawa penyakit kanser kolorektal dilaporkan paling banyak menyerang lelaki (16.2 peratus) dan kedua terbanyak menyerang wanita (10.6 peratus) di Semenanjung Malaysia pada 2006.
"Pertubuhan Kesihatan Sedunia (WHO) melaporkan bahawa lebih 940,000 orang di seluruh dunia diserang kanser kolorektal setiap tahun dan daripada jumlah itu, hampir 500,000 meninggal dunia setiap tahun," katanya.
Rosnah berkata, kerajaan telah mengambil langkah bagi memastikan pusat gastroenterologi di hospital kerajaan dilengkapi peralatan dan teknologi terkini.
"Kebanyakan pusat ini dilengkapi kepakaran dan kemudahan paling moden bagi menyediakan perkhidmatan pengesanan bertaraf dunia serta perkhidmatan diagnosis dan terapeutik," katanya.
Rosnah berkata, kementerian berkenaan juga telah menubuhkan Pusat Pendaftaran Pesakit Kanser bagi mengumpul data secara sistematik mengenai semua perkara berkaitan kanser kolorektal di Malaysia termasuk pencegahan, pengurusan dan rawatan. - Bernama
Beliau berkata, pada 2006 dan 2007, penyakit berkaitan sistem penghadaman menduduki tangga ketujuh sebagai penyebab utama kematian di hospital kerajaan dan melonjak ke tangga keenam pada tahun 2008.
"Ini tidak memeranjatkan jika dilihat gaya hidup kebanyakan rakyat Malaysia," katanya ketika melancarkan sambutan Hari Penghadaman Sedunia di Ikano Power Centre di sini semalam.
Rosnah berkata, penyakit berkaitan sistem penghadaman yang paling banyak dihidapi rakyat Malaysia ialah refluks gastroesophageal (GERD), ulser peptik, sindrom kerengsaan usus (IBS) dan kanser usus.
"Penyakit kanser gastrointestinal khususnya, meningkat secara mendadak di Malaysia berdasarkan hakikat bahawa penyakit kanser kolorektal dilaporkan paling banyak menyerang lelaki (16.2 peratus) dan kedua terbanyak menyerang wanita (10.6 peratus) di Semenanjung Malaysia pada 2006.
"Pertubuhan Kesihatan Sedunia (WHO) melaporkan bahawa lebih 940,000 orang di seluruh dunia diserang kanser kolorektal setiap tahun dan daripada jumlah itu, hampir 500,000 meninggal dunia setiap tahun," katanya.
Rosnah berkata, kerajaan telah mengambil langkah bagi memastikan pusat gastroenterologi di hospital kerajaan dilengkapi peralatan dan teknologi terkini.
"Kebanyakan pusat ini dilengkapi kepakaran dan kemudahan paling moden bagi menyediakan perkhidmatan pengesanan bertaraf dunia serta perkhidmatan diagnosis dan terapeutik," katanya.
Rosnah berkata, kementerian berkenaan juga telah menubuhkan Pusat Pendaftaran Pesakit Kanser bagi mengumpul data secara sistematik mengenai semua perkara berkaitan kanser kolorektal di Malaysia termasuk pencegahan, pengurusan dan rawatan. - Bernama
August 12, 2010
Agen Pulau Gadong, Melaka
Agen bagi kawasan Pulau Gadong, Melaka
Pn Rafidah Johar 0172239254
Pn Rafidah Johar 0172239254
Rafidah Johar, Melaka (Diabetes & Darah Tinggi)
- Pesakit diabetes yang sentiasa perlu inject insulin
- Tahap glukos biasa 10 ke atas dan mencecah 20
- Mula makan 1/5/2010, selepas 5 hari tahap glukos turun kepada 5.8
- Walaupun makan tanpa sebarang pantang, mengambil coke, serta pelbagai jenis makanan manis, tahap glukos akan kembali turun selepas makan beberapa ulas black garlic
- Lain2 penyakit yang turut hilang ; sakit sendi jari kaki, lemah badan,
- Badan turut terasa cergas dan berpeluh
August 10, 2010
Selamat Menyambut Ramadhan Al Mubarak
Selamat menyambut Ramadhan kepada semua ahli Black Garlic Community, kepada agen agen Black Garlic dan juga kepada pelanggan Black Garlic seluruh Malaysia..
Agen terbaru Bandar Jengka Pahang
Agen Kawasan Bandar Jengka Pahang
En Kamaruddin Hamid, di SK Desa Jaya, Jln Hospital, Bandar Jengka.
Contact No : 0139315257
En Kamaruddin Hamid, di SK Desa Jaya, Jln Hospital, Bandar Jengka.
Contact No : 0139315257
__________________
August 09, 2010
Kepada penghidap MIGRAINE, Black Garlic memang berkesan untuk anda!!!
Makcik saya Pn Rekamsinah adalah penghidap MIGRAINE yang kronik..Selepas mengambil Black Garlic selama 2 minggu, dengan mengikut sukatan yang dicadangkan, ALHAMDULILLAH...TIADA LANGSUNG SEBARANG TANDA2 SEPERTI NAK KENA MIGRAINE SEPERTI SELALU SEBELUM INI. Menurut makcik saya, kebiasaannya, dahulu, setiap minggu ada sahaja tanda2 macam nak kena Mgraine attack so dia kena la standby kan ubat Migraine all the time..Sekarang selepas 2 minggu, Alhamdullah...tiada langsung tanda2 seperti dulu...
Makcik saya Pn Rekamsinah adalah penghidap MIGRAINE yang kronik..Selepas mengambil Black Garlic selama 2 minggu, dengan mengikut sukatan yang dicadangkan, ALHAMDULILLAH...TIADA LANGSUNG SEBARANG TANDA2 SEPERTI NAK KENA MIGRAINE SEPERTI SELALU SEBELUM INI. Menurut makcik saya, kebiasaannya, dahulu, setiap minggu ada sahaja tanda2 macam nak kena Mgraine attack so dia kena la standby kan ubat Migraine all the time..Sekarang selepas 2 minggu, Alhamdullah...tiada langsung tanda2 seperti dulu...
August 08, 2010
Agen terbaru di Bentong, Pahang
PENGUMUMAN...AGEN TERBARU DI KAWASAN BENTONG PAHANG.. EN WAFDI KAMIL - 0192402502
August 05, 2010
Cara Makan Black Garlic di Bulan Ramadhan...
Bagi pengambilan Black Garlic di bulan Ramadhan, anda cuma tidak perlu makan Black Garlic pada waktu tengahari. Akan tetapi boleh lebihkan sedikit pengambilan Black Garlic sewaktu time dah berbuka, lebih2 lagi kalau berbuka dengan makanan yang terlalu manis/ terlalu berat..
Tapi bagi yang sudah menyesuaikan pengambilan mengikut keadaan tubuh sendiri, anda boleh makan Black Garlic mengikut kesesuaian anda.
Yang penting kita sihat!!!
Tapi bagi yang sudah menyesuaikan pengambilan mengikut keadaan tubuh sendiri, anda boleh makan Black Garlic mengikut kesesuaian anda.
Yang penting kita sihat!!!
August 03, 2010
Email dari Anak En Abdollah
Di sini saya ingin juga kongsi kan bersama semua email yang dihantar oleh anak En Abdollah kepada saya sewaktu ingin mendapatkan Black Garlic daripada saya
From A****a Abdollah
to Rich Power House Sdn Bhd
date Sat, Jun 12, 2010 at 8:35 AM
subject Re: Black Garlic
mailed-by yahoo.com
signed-by yahoo.com
Salam,
Bapa saya darah tinggi, dlu kena mild strok tapi kini dah ok. Baru2 ni kawan abah rekomen makan black garlic dah alhamdullillah darahnye ok. So sekarang ni dah kehabisan stok, sebab tu dia suruh saya cari. Saya pun ada rekomen kat kawan2 so lanie diaorang suruh saya cari kat mana boleh dpt black garlic. Nanti beritau ye!
to Rich Power House Sdn Bhd
date Sat, Jun 12, 2010 at 8:35 AM
subject Re: Black Garlic
mailed-by yahoo.com
signed-by yahoo.com
Salam,
Bapa saya darah tinggi, dlu kena mild strok tapi kini dah ok. Baru2 ni kawan abah rekomen makan black garlic dah alhamdullillah darahnye ok. So sekarang ni dah kehabisan stok, sebab tu dia suruh saya cari. Saya pun ada rekomen kat kawan2 so lanie diaorang suruh saya cari kat mana boleh dpt black garlic. Nanti beritau ye!
Testimoni En Abdollah, Muar
Encik Abdollah menghidap penyakit darah tinggi, dan mempunyai masalah prostate.
Kini beliau menjadi agen Black Garlic bagi Daerah Muar, Johor
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